Farhan Raza Khan 1
1 Assist Prof. & Program Director Operative Dentistry Aga Khan University, Karachi, 74800 Pakistan
*Corresponding author: “Dr Farhan Raza Khan ” < firstname.lastname@example.org >
Volume 23, Issue 2 (April - June 2014)
Single nucleotide polymorphisms (SNPs) in the promoter region of the b-defensin gene DEFB1 have recently been shown to be associated with altered risk of developing caries in permanent dentition.
We therefore sought to establish whether DEFB1 SNPs conferred a similar risk in primary dentition.
DEFB1 genotypes (rs11362 and rs1800972) were studied in 178 children, of whom 92 had caries.
No association between genotype and phenotype was detected, even when more severe caries was considered as the phenotype. These and other data suggest that non-genetic factors may be greater modifiers of caries risk in primary dentition.
DECLARATION OF INTERESTS:
There are no conflicts of interest to declare.
Dental caries, primary dentition, -defensin, single nucleotide polymorphism.
How to CITE:
Mubayrik AFB, Deelay K, Patir A, Koruyucu M, Seymen F, Vieira AR. DEFB1 polymorphisms and caries in primary dentition. J Pak Dent Assoc 2014; 23(2):66-69.