Farhan Raza Khan 1
1 Assist Prof. & Program Director Operative Dentistry Aga Khan University, Karachi, 74800 Pakistan
*Corresponding author: “Dr Farhan Raza Khan ” < farhan.raza@aku.edu >
Volume 23, Issue 2 (April - June 2014)
Open Access
BACKGROUND:
Single nucleotide polymorphisms (SNPs) in the promoter region of the b-defensin gene DEFB1 have recently been shown to be associated with altered risk of developing caries in permanent dentition.
OBJECTIVE:
We therefore sought to establish whether DEFB1 SNPs conferred a similar risk in primary dentition.
METHODOLOGY:
DEFB1 genotypes (rs11362 and rs1800972) were studied in 178 children, of whom 92 had caries.
CONCLUSION:
No association between genotype and phenotype was detected, even when more severe caries was considered as the phenotype. These and other data suggest that non-genetic factors may be greater modifiers of caries risk in primary dentition.
DECLARATION OF INTERESTS:
There are no conflicts of interest to declare.
KEY WORDS:
Dental caries, primary dentition, -defensin, single nucleotide polymorphism.
How to CITE:
Mubayrik AFB, Deelay K, Patir A, Koruyucu M, Seymen F, Vieira AR. DEFB1 polymorphisms and caries in primary dentition. J Pak Dent Assoc 2014; 23(2):66-69.